T-cell receptor early signalling complex activation in response to interferon-α receptor stimulation

T-cell receptor early signalling complex activation in response to interferon-α receptor stimulation

Signalling through the IFNalphaR (interferon-alpha receptor) and TCR (T-cell receptor) in Jurkat T lymphocytes results in distinct immune responses. Despite this both receptors elicit ERK (extracellular-signal-regulated kinase)/MAPK (mitogen-activated protein kinase) phosphorylation. Vav and Slp76 are shown to be required for IFNalpha (interferon-alpha)-stimulated ERK activity. These form a sub...

T cell receptor signalling.

Upon engagement of the TCR by antigen presented on major histocompatibility complex (MHC) molecules, the Src family kinase Lck is activated and proceeds to phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the ε, δ, γ and ζ subunits of the TCR. Phosphorylated ITAMs promote the recruitment and subsequent activation of another tyrosine kinase ZAP-70. Two known substrates of...

Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation.

The central zone of the supramolecular activation cluster (c-SMAC) is a zone of T cell receptor (TCR) enrichment that forms at a T cell/antigen-presenting cell (APC) junction in response to antigen stimulation. We demonstrate that there is a surprisingly complex relocalization process that brings PKC and Bcl10, two intermediates in TCR activation of NF-kappaB, to the cytoplasmic face of the c-S...

The Interferon alpha receptor utilises T - cell receptor - associated proteins for signalling

Activation of cytotoxic T-cell receptor gd T lymphocytes in response to specific stimulation in myelodysplastic syndromes

Results Vγ9Vδ2 T cells, the major circulating γδ T-cell subset, were reduced in myelodysplastic syndromes, but mainly in myelodysplastic syndromes’ patients with associated autoimmune diseases, suggesting that this anomaly was largely due to the autoimmune component. On the other hand, bromohalohydrin pyrophosphate-induced expansion of the Vγ9Vδ2 T-cell population in all 15 control samples, but...